Description
Stigmasteryl hemisuccinate (STEMS) is a stigmasterol derivative that is responsive to changes in pH. Stigmasteryl is a naturally occurring phytosterol lipid that is growing in the bioprocessing space for its ability to improve lipid nanoparticle (LNP)-based mRNA transfection efficiency. Conjugation to hemiscuccinate has been shown to improve the cellular uptake in acidic microenvironments, such as those around tumors.