Description
1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE) is a neutral helper phospholipid used in gene and drug delivery liposomal formulations. When used in combination with charged lipids, helper lipids have been shown to increase the transfection efficiency in a variety of cell types. DOPE is efficient at facilitating endosomal escape by disrupting membranes.