Description
1,2-distearoyl-sn-glycero-3-phospho-rac-glycerol (DSPG) is an anionic phospholipid in liposomal drug and gene delivery formulations. Anionic phospholipids promote liposomal membrane disruption allowing for release of the drug payload. Anionic lipoplexes, formulated with a combination of anionic and zwitterionic lipids, have also demonstrated high DNA entrapment capability and high stability.